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Memory Enhancement Noopept Pharmaceutical Steroids CAS 157115-85-0 No Side Effects
Product Name: Noopept; N-(1-(Phenylacetyl)-L-prolyl)glycine ethyl ester
CAS No.: 157115-85-0
Molecular Formula: C17H22N2O4
Molecular Weight: 318.37
Appearance: White off-white crystalline powder
Storage: Store in well-closed container, protec...
Application: The product is used as chemical reage.....
Noopept is considered a nootropic drug with neuroprotective properties. It is reported to improve learning ability and memory (including the initial processing of information, consolidation, and retrieval). It is also used to prevent the development of amnesia induced by electroshock.
In animal studies, Noopept helped to restore memory and other cognitive functions disturbed as a result of ischemia as well as damage due to hypoxia (a condition in which the body or region of the body is deprived of adequate oxygen supply). The therapeutic effect of the drug in patients with organic disorders of the central nervous system appeared within 5-7 days of treatment. Also reported was the reduction or disappearance of anxiety, irritability, emotional lability and sleep disorders.
It has also been observed to reverse and prevent learned helplessness neurosis in rats after long term (21 day) treatment.
It is derived from the racetam family of drugs and shares similar mechanisms of action, but is, according to studies, 1000 times more potent than the prototypical racetam drug, piracetam.Animal studies have shown noopept to be neuroprotective and enhance memory in various tests. Since it is a peptide-derived compound, noopept is degraded by enzymes in the GI tract and liver. Its oral bioavailability has been shown to be much lower than other routes of administration, with serum concentrations reaching 10% of IV levels per-orally. It does show good blood–brain barrier penetration in rats (although a previous study concluded that "GVS-111 itself was not found in rat brain 1 h after 5 mg/kg i.p. administration up to limit of detection" and that administration of Noopept only increases the concentration of endogenous nootropic cyclo-L-prolylglycine), and human studies have shown promising results, with potential application in the treatment of Alzheimer's disease. It is also an "immunocorrector" in mice. Noopept attenuates apoptosis and tau hyperphosphorylation in an animal model of Alzheimer disease. 
Noopept normalizes some parameters in rats with experimental diabetes.It has been found to stimulate the expression of NGF and BDNF in rat hippocampus. Expression of the studied neurotropic factors in the cerebral cortex was below the control after single administration of Noopept, while chronic administration caused a slight increase in BDNF expression. In the hippocampus, expression of mRNA for both neurotrophins increased after acute administration of Noopept. Chronic treatment with Noopept was not followed by the development of tolerance, but even potentiated the neurotrophic effect.
|Assay(As Dried Base,%)||98.5% to 101%||99.68%||HPLC|
|Color||White to Colourless||Complies||Visual|
|Loss on Drying||≤1.0%||0.35%||USP|
|Residue on ignition||≤0.5%||0.08%||USP|
|Heavy metals (As Pb)||NMT20PPM||Conforms||USP|
|Related substance||Meet the requirements||Conforms||USP|
|Packing and Storage|
|Packing||Pack in paper-drums and two plastic-bags inside. 25kg/drum|
|Storage||Store in a well-closed container away from moisture and direct sunlight.|
|Shelf Life||3 years if sealed and stored properly.|
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